Department of Chemical and Biomolecular Engineering
North Carolina State University
College of Engineering 1, Box 7905
911 Partners Way
Raleigh, NC 27695-7905
http://turbo.che.ncsu.edu/alex
PhD Chemical and Biomolecular Engineering, North Carolina State University, 2006
M.S. Chemical Engineering, North Carolina State University, 2002
B.S.E. Chemical Engineering, University of Pennsylvania, 2000
Fellow, N.I.H. Biotechnology Training Program at North Carolina State University
Graduate Research Doctoral Research with Dr. Carol Hall on “Simulation of Polyglutamine Aggregation Using an Intermediate Resolution Protein model” (May 2001 - Present)
Internship Bristol Myers Squibb Company “Automation of supercritical fluid chromatography unit for use in separation of chiral compounds” (August 2003)
Undergraduate Research
-with Dr. David Graves, University of Pennsylvania Department of Chemical Engineering “Adsorption of DNA on treated glass slides” (June 1999-May 2000)
-with Dr. Eduardo Glandt, University of Pennsylvania Department of Chemical Engineering “Computer simulations of vapor-liquid equilibrium on surfaces”(October 1998 – May 1999)
-with Dr. Perla Balbuena, University of South Carolina Department of Chemical Engineering “Computer simulations of interactions between carbon dioxide and benzene” (June – August 1998)
Teaching Assistant for Quantitative Chemistry Laboratory, Chemistry, North Carolina State University Department of Chemistry (August 2000-May 2001)
L. A. F. Coelho, A. Marchut, J. V. de Oliveira, and P. B. Balbuena, "Theoretical Studies of Energetics and Diffusion of Aromatic Compounds in Supercritical Carbon Dioxide," Industrial and Engineering Chemistry Research, 39, 227 (2000).
H. D. Nguyen, A. J. Marchut, and C. K. Hall, “Solvent Effects on the Conformational Transition of a Model Polyalanine Peptide,” Protein Science, 13, 2909 (2004).
C. K. Hall, H. D. Nguyen, A. J. Marchut, and V. Wagoner “Protein Aggregation Simulations: A Review,” to appear in “Misbehaving Proteins: Protein (Mis)Folding, Aggregation and Stability,” R. M. Murphy and A. M. Tsai, Eds., Kluwer Academic Press, 2005.
A. J. Marchut and C. K. Hall, “Spontaneous Formation of Annular Structures Observed in Molecular Dynamics Simulations of Polyglutamine Peptides” Computational Biology and Chemistry, accepted.
A. J. Marchut and C. K. Hall “Sidechain interactions determine amyloid formation by model polyglutamine peptides in molecular dynamics simulations” Biophysical Journal, accepted.
A. J. Marchut and C. K. Hall “Effects of Chain Length on the Aggregation of Model Polyglutamine Peptides” Proteins, submitted.
Presentations
H. D. Nguyen, A. J. Marchut, and C. K. Hall, “Molecular dynamics simulations of protein aggregation including fibril formation,” poster presented at Fourth Biannual Triangle Biophysics Symposium, Chapel Hill, NC, November 2002.
A. J. Marchut and C. K. Hall, “Polyglutamine Aggregation Simulations: Development of an Intermediate Resolution Protein Model,” oral presentation at American Institute of Chemical Engineers Annual Conference, San Francisco, CA, November 2003.
A. J. Marchut and C. K. Hall “Simulation of Polyglutamine Aggregation With An Intermediate Resolution Protein Model- Preliminary Results,” poster presented at FASEB Amyloid Conference 2004.
A. J. Marchut and C. K. Hall, “Simulation of Polyglutamine Aggregation With An Intermediate Resolution Protein Model,” oral presentation at American Institute of Chemical Engineers Annual Conference, Austin, TX, November 2004.
A. J. Marchut and C. K. Hall, “Simulation of Polyglutamine Aggregation With An Intermediate Resolution Protein Model,” poster presented at Thermo 2005, College Park, MD
A. J. Marchut and C. K. Hall, “Simulation of Polyglutamine Aggregation With An Intermediate Resolution Protein Model,” oral presentation at American Institute of Chemical Engineers Annual Conference, Cincinnati, OH, October 2005.
Computer: Experienced with and proficient with various computer software packages and languages including FORTRAN, Scheme, C++, BASIC, Mathcad, Maple, Matlab, Excel, Word, Powerpoint, and chemical simulation packages such as Gauss94, CHARMM, DISCOVER, CHEMSEP, ASPEN, and HYSYS. Familiar and experienced with computer operating systems including Windows, Macintosh, DOS, Unix, and Linux. Extensive experience with Red Hat Linux system administration
Laboratory: Trained in basic laboratory techniques such as titration, separation, reaction analysis, use of centrifuge, graphical analysis and interpolation of data, use of oscilloscope, use of pipettes, AC/DC circuit set-up, Beer-Lambert Law analysis and calculations, set-up and run of electrophoresis gels, recombinant protein expression and purification, liquid and supercritical fluid chromatography, use of computer software for data collection and manipulation including use of a computer/laser set-up, and computer/microscope with Xenon Arc Lamp set-up and familiar with laboratory safety and sterile procedures and proper maintenance of tools and supplies (various types of glassware, solutions, and electromagnetic, laser, UV, and high powered light equipment). Familiar with laser scanners including focusing, data capture, and analysis.
Languages: Fluent in English, French, and American Sign.
Computer System Administrator, Carol K. Hall's Applied Thermodynamics Research Group, North Carolina State University (July 2002- Present)
Webmaster, North Carolina State University Department of Chemical and Biomolecular Engineering (July 2004-Present)
Graduate Student Recruiting Captain, North Carolina State University Department of Chemical and Biomolecular Engineering (2004)
Member, Hexagon Senior Engineering Society University of Pennsylvania (1999-2000)
President, Pi Lambda Phi fraternity, University of Pennsylvania (1998-1999)
Rush Chairman, Pi Lambda Phi fraternity, University of Pennsylvania (1997-1998)
Member, Wind Ensemble, University of Pennsylvania (1996-1997)